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The pattern electroretinogram in optic nerve disease.

W Seiple, M J Price, M Kupersmith

    Ophthalmology
    |September 1, 1983
    PubMed
    Summary
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    Pattern evoked electroretinograms (PERG) effectively detect optic nerve disease, even in mild cases. PERGs are abnormal when visual acuity is reduced, unlike diffuse flash electroretinograms (ERG).

    Area of Science:

    • Ophthalmology
    • Neuroscience
    • Visual Electrophysiology

    Background:

    • Optic nerve disease can impact visual function.
    • Accurate diagnosis is crucial for timely intervention.
    • Assessing visual pathway function requires sensitive diagnostic tools.

    Purpose of the Study:

    • To evaluate the diagnostic utility of pattern evoked electroretinograms (PERG) in unilateral optic nerve disease.
    • To compare PERG findings with diffuse flash electroretinograms (ERG) and visual evoked potentials (VEP).
    • To determine PERG's sensitivity in detecting mild optic nerve dysfunction.

    Main Methods:

    • Recruitment of patients with unilateral optic nerve disease.
    • Performance of pattern evoked electroretinograms (PERG), diffuse flash electroretinograms (ERG), and visual evoked potentials (VEP).

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  • Correlation of electrophysiological findings with Snellen visual acuity and contrast thresholds.

    • Main Results:

    • Patients with visual acuity <6/30 had unrecordable PERGs, normal diffuse flash ERGs, and reduced/absent VEPs.
    • Patients with visual acuity 6/6 to 6/30 showed reduced PERG amplitudes in affected eyes.
    • All affected eyes exhibited abnormal contrast thresholds measured by PERG amplitude.

    Conclusions:

    • Pattern evoked electroretinograms (PERG) are valuable for diagnosing optic nerve disease.
    • PERG is sensitive in detecting even mildly affected cases.
    • PERG findings correlate with visual acuity deficits in optic nerve disease.