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Related Experiment Video

Updated: Jul 23, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

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Parathyroid response during therapeutic plasma exchange.

M B Bongiovanni, J E Strauss, E M Ziselman

|November 1, 1983

Summary

Therapeutic plasma exchange rarely causes low calcium. Increased parathyroid hormone secretion during this procedure may help maintain normal calcium levels.

Area of Science:

Endocrinology
Nephrology
Hematology

Background:

Therapeutic plasma exchange (TPE) is a medical procedure involving the removal of plasma from the blood.
Hypocalcemia, or low calcium levels, can be a potential complication during TPE.
Maintaining calcium homeostasis is crucial for various physiological functions.

Purpose of the Study:

To investigate the incidence of significant hypocalcemia during therapeutic plasma exchange.
To explore the potential role of parathyroid hormone (PTH) in calcium regulation during TPE.

Main Methods:

Observational study analyzing patient data during TPE procedures.
Monitoring of serum calcium and parathyroid hormone levels before, during, and after TPE.

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Main Results:

Significant hypocalcemia was infrequently observed during TPE.
A notable increase in parathyroid hormone secretion was detected during TPE procedures.
Elevated PTH levels correlated with the maintenance of calcium levels.

Conclusions:

The study suggests that increased parathyroid hormone secretion is a compensatory mechanism during TPE.
This hormonal response may effectively prevent significant hypocalcemia in most patients undergoing TPE.
Further research can elucidate the precise interplay between TPE, calcium, and PTH.