Related Experiment Video
Updated: Aug 10, 2026

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
Published on: November 25, 2017
Distribution and characteristics of polysialosyl oligosaccharides in nervous tissue glycoproteins
Abstract:
Large polysialosyl glycopeptides can be derived from the glycoproteins of both mature as well as early postnatal brain, although their concentration (in terms of sialic acid content) decreases by approximately 75 percent during the first month in rat brain. These glycopeptides were found to contain O-sulfate residues, and subcellular fractionation studies indicated that most of the glycoproteins having polysialosyl units are present in non-synaptic plasma membranes. Large polysialosyl glycopeptides can also be obtained from the membranes of PC12 pheochromocytoma cells, demonstrating that this type of structure is not unique to brain.
Related Concept Videos
Glial Cells
Protein Glycosylation
Glycosylation occurs in...
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Proteoglycans
Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
Nervous Tissue: Glial Cells
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...

