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Alcohol-induced pseudo-Cushing's syndrome
Lancet (London, England)
|April 2, 1977
Summary
Excessive alcohol intake can mimic Cushing's syndrome, leading to misdiagnosis. Identifying alcohol consumption is crucial for accurate diagnosis, as symptoms resolve with ethanol withdrawal.
Area of Science:
- Endocrinology
- Internal Medicine
- Clinical Diagnostics
Background:
- Cushing's syndrome is characterized by prolonged exposure to high cortisol levels.
- Differential diagnosis is essential to distinguish true endocrine disorders from conditions with similar presentations.
Observation:
- Four patients presented with corticosteroid hypersecretion due to excessive alcohol intake.
- This clinical picture initially led to an incorrect diagnosis of Cushing's syndrome in these patients.
Findings:
- Pseudo-Cushing's syndrome, induced by alcohol, presents with hormonal abnormalities mimicking Cushing's syndrome.
- These abnormalities are reversible and resolve upon cessation of alcohol consumption (ethanol withdrawal).
Implications:
- A thorough patient history, specifically inquiring about alcohol intake, is vital when Cushing's syndrome is suspected.
- This proactive diagnostic step can prevent misdiagnosis and ensure appropriate patient management.
- Recognizing alcohol-induced pseudo-Cushing's syndrome facilitates timely intervention and recovery.