Contact dermatitis to Synthaderm

Allergic contact dermatitis is described in 2 patients treated with Synthaderm, a polyurethane covering for leg ulcers. One of the patients was patch tested with 3 extractions made from Synthaderm as well as with 5 isocyanate compounds. Her patch tests were negative to both extractions and isocyanates, but positive to Synthaderm samples with different batch numbers and years of production.