Dynamics of H1(0) content in rat liver after partial hepatectomy

The changes in the lysine-rich histone subfraction H1(0) have been quantitatively studied in rat liver during the regeneration period after partial hepatectomy. A gradual decrease in this protein was found early after operation with a minimal value around the time of maximal mitotic activity. The reduction in the H1(0) content paralleled well the increasing number of cells in the cell cycle.