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Related Experiment Videos

Acute chlordane intoxication.

L S Olanoff, W J Bristow, J Colcolough

    Journal of Toxicology. Clinical Toxicology
    |June 1, 1983
    PubMed
    Summary
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    A patient survived a massive chlordane pesticide overdose, showing severe symptoms and prolonged elimination. This case highlights chlordane

    Area of Science:

    • Toxicology
    • Pharmacokinetics

    Background:

    • Accidental ingestion of large quantities of pesticides can lead to severe health consequences.
    • Understanding the absorption, distribution, metabolism, and excretion (ADME) of toxicants is crucial for clinical management.
    • Chlordane is an organochlorine pesticide with known toxicity.

    Observation:

    • A patient ingested 215g of chlordane, presenting with vomiting, diarrhea, seizures, coma, and respiratory failure.
    • Blood and urine samples revealed chlordane disposition and elimination over 49 days.
    • Tissue samples showed persistent chlordane metabolite residues 58 days post-ingestion.

    Findings:

    • Chlordane exhibited a multicompartmental kinetic profile in whole blood.
    • The terminal elimination half-life of chlordane was approximately 34 days.

    Related Experiment Videos

  • High levels of chlordane metabolites were detected in tissues long after ingestion.

    • Implications:

    • This case provides valuable data on the physiological distribution and elimination of chlordane in humans.
    • Findings can inform clinical management strategies for patients with acute chlordane intoxication.
    • Understanding pesticide residue persistence is vital for assessing long-term health risks.