Auto-immune therapy against human allergic disease: a physiological self defence factor

Area of Science:

• Immunology and Allergy Research
• Physiological Self-Defense Mechanisms

Background:

• Ovalbumin-sensitized guinea pigs excrete urine containing ovalbumin.
• This excreted ovalbumin prevents anaphylactic death in guinea pigs.

Purpose of the Study:

• To investigate the therapeutic potential of bodily secretions in controlling allergic reactions.
• To establish effective physiological self-defense strategies against allergic challenges in humans.

Main Methods:

• Bio-assay to determine effective doses of urine from allergic patients.
• Monitoring for the disappearance of buccal sensation to identify the neutralization dose.
• Application of salivary, nasal, and sweat secretions to the conjunctiva.

Main Results:

• Sublingual administration of urine from allergic patients effectively controlled their allergic symptoms.
• The neutralization dose was identified by the absence of buccal sensation.
• Topical application of secretions to the conjunctiva also managed allergic symptoms.

Conclusions:

• Bodily secretions, like urine and sweat, contain therapeutic agents for managing allergies.
• Physiological self-administration of these secretions offers a viable self-defense therapy for human allergies.
• This approach presents a novel, natural method for controlling allergic responses.