[Comparative studies of amoxicillin resorption and distribution in poultry]

Comparative experiments were carried out to test the resorption and retention of amoxicillin-trihydrate, ampicillin-trihydrate and amopen-powder Pharmachim drug formula (containing 5 per cent amoxicillin-trihydrate) following a single oral application to chickens and wild ducks. Higher was the resorption of amoxicillin as a trihydrate in comparison to ampicillin as trihydrate (it provides concentrations twice as high in the blood of chickens). The ducks were found to utilize amoxicillin as trihydrate in a similar manner, however, they excrete it more rapidly. The distribution of the preparation was determined in the viscera of chickens treated with amoxicillin via the feed at the rate of 20.0 /kg feed in the course of six days. It was found that amoxicillin was retained in therapeutic concentrations in the liver, kidneys, lungs, and muscles, and in lower concentrations in the spleen and heart. It was established that the brain also contained negligible amounts of the preparation. The tissue concentrations did not surpass the serum ones.