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Lactate dehydrogenase activity in ocular tumors
Annals of Ophthalmology
|April 1, 1983
Summary
Lactate dehydrogenase (LDH) levels in serum and aqueous humor are significantly elevated in malignant ocular tumors compared to benign tumors and normal eyes. This finding is particularly notable in retinoblastoma cases.
Area of Science:
- Ophthalmology
- Biochemistry
- Oncology
Background:
- Ocular tumors, both benign and malignant, present unique diagnostic challenges.
- Lactate dehydrogenase (LDH) is an enzyme found in many body tissues, and its elevated levels can indicate tissue damage or disease.
Purpose of the Study:
- To investigate and compare lactate dehydrogenase (LDH) activity in the aqueous humor and serum of patients with benign ocular tumors, malignant ocular tumors, and healthy individuals.
- To determine if LDH levels can serve as a biomarker for differentiating between benign and malignant ocular conditions.
Main Methods:
- Serum and aqueous humor samples were collected from three groups: 15 patients with benign ocular tumors, 15 patients with malignant ocular tumors, and 15 normal control subjects.
- Lactate dehydrogenase (LDH) activity was measured in all collected samples.
Main Results:
- Significantly higher levels of LDH were observed in both serum and aqueous humor of patients with malignant ocular tumors compared to those with benign tumors and normal controls.
- Total LDH activity was markedly elevated in malignant tumor cases, with a specific emphasis on retinoblastoma.
Conclusions:
- Elevated serum and aqueous LDH levels are indicative of malignant ocular tumors.
- LDH activity may be a valuable biochemical marker for the diagnosis and differentiation of ocular tumors, especially retinoblastoma.