[Thyroid hormones and phospholipase activity in rat liver mitochondria]

The rate of the hydrolysis of mitochondrial phospholipids isolated from the liver of rats given excess amount of thyroid hormones for a long time was higher than in normal animals. Activation of this process determined by endogenous phospholipase of mitochondria could be also observed in liver mitochondria isolated 2 days after a single injection of L-thyroxine into rats. It is assumed that the hyperthyrosis-induced acceleration of lipid peroxidation in these organelles might be one of the reasons for activation of endogenous phospholipase of mitochondria.