Ultrastructural modifications in platelet membranes and cytoskeleton following activation

Platelet stimulus-activation-contraction-secretion coupling is linked to fundamental modifications in the biochemistry and ultrastructure of membranes and the cytoskeletal system. The nature of the physical changes and their relationships to biochemical events are just beginning to emerge. The present discussion examines basic changes occurring in the peripheral zone and cytoskeleton following platelet activation. Examination of the current state of knowledge may foment new interest in this important area of research.