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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

The relation of blood pressure to stroke prognosis

S W Rabkin, F A Mathewson, R B Tate

    Annals of Internal Medicine
    |July 1, 1978
    PubMed

    Insights

    High systolic blood pressure and significant increases in systolic blood pressure over 5 years before a stroke predict a worse prognosis. This finding is crucial for stroke survival prediction.

    Area of Science:

    • Neurology
    • Cardiology
    • Epidemiology

    Background:

    • Stroke remains a leading cause of mortality and disability worldwide.
    • Predictive factors for post-stroke survival are essential for clinical management.
    • Previous blood pressure readings may offer insights into stroke outcomes.

    Purpose of the Study:

    • To investigate the association between pre-stroke blood pressure and survival.
    • To determine if blood pressure changes over time impact stroke prognosis.

    Main Methods:

    • Analysis of the Manitoba study cohort (3983 men).
    • Utilized last recorded blood pressure before stroke and 5-year change in blood pressure.
    • Multivariate analysis adjusted for age at stroke and ischemic heart disease.

    Main Results:

    • Elevated systolic blood pressure and its 5-year increase were linked to poorer prognosis.
    • Systolic blood pressure and its 5-year change significantly predicted 30-day mortality.
    • Systolic blood pressure was a stronger predictor of short-term mortality than diastolic pressure.

    Conclusions:

    • Pre-stroke high systolic blood pressure is a significant predictor of poor short-term survival.
    • A substantial 5-year increase in systolic blood pressure before stroke indicates a worse prognosis.
    • Systolic blood pressure is a key factor in predicting short-term mortality after stroke.

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