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Acyclovir treatment in stromal herpetic keratitis
Documenta Ophthalmologica. Advances in Ophthalmology
|December 15, 1983
Summary
Herpes simplex keratitis (HSK) can be effectively treated with acyclovir ointment and corticosteroids, leading to rapid healing. However, corticosteroids are crucial for preventing recurrences of stromal corneal edema, as acyclovir alone was insufficient.
Area of Science:
- Ophthalmology
- Virology
- Pharmacology
Background:
- Herpes simplex keratitis (HSK) is a significant cause of corneal blindness.
- Deep stromal HSK presents a therapeutic challenge due to potential for recurrence and visual impairment.
- Previous treatments for HSK have varied efficacy and side effect profiles.
Purpose of the Study:
- To evaluate the efficacy of 3% acyclovir ointment in combination with corticosteroids for treating deep stromal HSK.
- To assess the role of acyclovir and corticosteroids in preventing HSK recurrences.
- To determine the safety profile of acyclovir ointment in HSK management.
Main Methods:
- A cohort of 35 patients with long-standing deep stromal HSK was treated.
- Treatment involved the topical application of 3% acyclovir ointment.
- Corticosteroids were administered in tapering dosages to manage inflammation and prevent recurrence.
Main Results:
- All 35 patients achieved clinical cure within 2 to 4 weeks.
- Treatment success was independent of disease duration and prior antiviral use.
- Recurrences of stromal corneal edema were prevented by long-term corticosteroid use, not acyclovir.
- No significant adverse effects were observed with acyclovir ointment.
Conclusions:
- Topical acyclovir is effective for acute deep stromal HSK treatment.
- Corticosteroids are essential for long-term management and prevention of HSK recurrence.
- Acyclovir ointment demonstrates a favorable safety profile in HSK patients.