Comparative penetration of latamoxef (moxalactam) and cefazolin into human knee following simultaneous administration

The penetration of latamoxef (moxalactam) and cefazolin into cancellous bone was compared in ten adult patients undergoing total knee replacement. Each patient received a ten milligram per kilogram bolus dose of both antibiotics at the induction of anaesthesia. Antibiotic bone concentrations were determined by HPLC. The mean serum concentrations of cefazolin were significantly greater (P less than 0.01) than those of latamoxef at all time periods. The absolute bone concentrations of cefazolin and latamoxef did not differ significantly (P greater than 0.05). The method of simultaneous administration offers significant advantages over the conventional two group study design.