Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abnormal facial development in the mouse mutant first arch.

D M Juriloff, M J Harris

    Journal of Craniofacial Genetics and Developmental Biology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Algebraic Loop Liquid in the Pyrochlore CsNiCrF_{6}.

    Physical review letters·2026
    Same author

    Seatbelt use among bus passengers in Ghana: observed versus self-reported measures.

    International journal of injury control and safety promotion·2022
    Same author

    A retrospective analysis of factors associated with anesthetic case duration for cesarean deliveries.

    International journal of obstetric anesthesia·2018
    Same author

    [Blistering lesions after contact with plants].

    Anales de pediatria (Barcelona, Spain : 2003)·2016
    Same author

    A single-crystal neutron scattering study of lattice melting in ferroelastic [Formula: see text].

    Journal of physics. Condensed matter : an Institute of Physics journal·2011
    Same author

    Negative symptoms in late-life schizophrenia.

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2011
    Same journal

    Bone mineral density in the growing human mandible.

    Journal of craniofacial genetics and developmental biology·2001
    Same journal

    Palate vault morphology in Down syndrome.

    Journal of craniofacial genetics and developmental biology·2001
    Same journal

    Interrelation between fusions in the primary dentition and agenesis in the succedaneous permanent dentition seen from an embryological point of view.

    Journal of craniofacial genetics and developmental biology·2001
    Same journal

    Correlation of HSP110 expression with all-trans retinoic acid-induced apoptosis.

    Journal of craniofacial genetics and developmental biology·2001
    Same journal

    Secalonic acid D alters the expression and phosphorylation of the transcription factors and their binding to cAMP response element in developing murine secondary palate.

    Journal of craniofacial genetics and developmental biology·2001
    Same journal

    Dentition development and budding morphogenesis.

    Journal of craniofacial genetics and developmental biology·2001
    See all related articles

    The first arch mutation (far) in mice causes severe craniofacial defects, including cleft palate and abnormal vibrissae. These defects originate from the maxillary facial process during early embryonic development.

    Area of Science:

    • Developmental biology
    • Craniofacial genetics
    • Mouse models of birth defects

    Background:

    • The first branchial arch is crucial for craniofacial development.
    • Mutations affecting the first arch can lead to severe birth defects.

    Purpose of the Study:

    • Characterize craniofacial defects in mice homozygous for the 'far' mutation.
    • Investigate potential heterozygote expression.
    • Determine the embryogenesis of these defects.

    Main Methods:

    • Genetic analysis of 'far' homozygous mice at day 18 of gestation.
    • Developmental study of 'far' embryos at day 12 of gestation.

    Main Results:

    • Homozygotes exhibit cleft palate, pointed snout, disorganized vibrissae, and open eyes.

    Related Experiment Videos

  • Absence of infraorbital vibrissae and presence of facial skin tags are common in homozygotes.
  • Defects in palatal shelves and vibrissal ridges, along with abnormal trigeminal nerve development, are evident by day 12.

    • Conclusions:

    • The 'far' mutation specifically affects the maxillary facial process of the first branchial arch.
    • Craniofacial defects in 'far' homozygotes stem from abnormalities present by day 12 of gestation.
    • The study identifies specific phenotypic markers for identifying affected embryos for further research.