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Carbon disulphide intrauterine sensitization.

S Tabacova, B Nikiforov, L Balabaeva

    Journal of Applied Toxicology : JAT
    |October 1, 1983
    PubMed
    Summary

    Carbon disulfide (CS2) exposure during pregnancy caused increased birth defects in the second generation of rats. This suggests intrauterine sensitization may alter fetal development and hormonal programming.

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    Area of Science:

    • Toxicology
    • Developmental Biology
    • Reproductive Science

    Background:

    • Carbon disulfide (CS2) is a known teratogen.
    • The transgenerational effects of prenatal CS2 exposure are not well understood.

    Purpose of the Study:

    • To evaluate the effects of maternal CS2 exposure during pregnancy on two subsequent generations of albino rats.
    • To investigate potential transgenerational impacts on prenatal and postnatal development.

    Main Methods:

    • Maternal rats were exposed to teratogenic and subteratogenic CS2 concentrations during gestation.
    • Offspring (F1) were reared to maturity, mated, and their pregnant dams (F1) were re-exposed to CS2.
    • Evaluated embryonic lethality, congenital malformations, metabolic indices, DNA, drug-metabolizing enzymes, postnatal development, and behavioral effects in F1 and F2 generations.

    Main Results:

    • A significant increase in CS2-induced teratogenicity was observed in the F2 generation compared to F1.
    • Retarded development of the mixed-function oxidase (MFO) system was noted in the F2 generation.
    • Increased postnatal behavioral effects and altered hexobarbital sleeping time were evident in the F2 generation.

    Conclusions:

    • Prenatal CS2 exposure can induce intrauterine sensitization, leading to enhanced teratogenic effects in subsequent generations.
    • CS2 may interfere with hormonal programming during intrauterine development, causing transgenerational effects.
    • This study highlights the potential for environmental toxins to cause heritable developmental abnormalities.

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