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Systemic disease caused by pneumococci.

G Colman, G Hallas

    The Journal of Infection
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Pneumococcal types 14 and 18 caused the most infections in young children, including pneumonia and meningitis. Type 1 strains were most common overall in this patient survey.

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    Area of Science:

    • Microbiology
    • Epidemiology
    • Infectious Diseases

    Background:

    • Pneumococci are a leading cause of bacterial infections worldwide.
    • Understanding pneumococcal type distribution is crucial for effective prevention and treatment strategies.
    • Previous studies have highlighted varying prevalence of different pneumococcal serotypes.

    Purpose of the Study:

    • To determine the type distribution of pneumococci in a cohort of 462 patients.
    • To identify specific pneumococcal types associated with severe infections in children under five.
    • To explore potential pre-disposing factors for pneumococcal infections.

    Main Methods:

    • Retrospective analysis of pneumococcal isolates from 462 patients.
    • Serotyping of isolated pneumococci to determine specific types.

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  • Clinical data review to correlate infection types and patient demographics.
  • Statistical analysis to identify common infection types and pre-disposing factors.

    • Main Results:

    • Streptococcus pneumoniae type 1 was the most frequently isolated serotype overall.
    • Pneumococcal types 14 and 18 were most prevalent in children under five years of age.
    • Common infections included pneumonia, meningitis, and septicaemia.
    • Pre-disposing factors identified were heavy drinking, head injury, respiratory infections, heart disease, liver disease, malignancy, viral infections, and spleen abnormalities.

    Conclusions:

    • Specific pneumococcal serotypes, particularly types 14 and 18, pose a significant risk to young children.
    • Pneumonia, meningitis, and septicaemia are the most common severe outcomes of pneumococcal infections.
    • Multiple underlying health conditions and lifestyle factors may predispose individuals to pneumococcal disease.