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Cows' milk-sensitive enteropathy.

J Walker-Smith, M Harrison, A Kilby

    Archives of Disease in Childhood
    |May 1, 1978
    PubMed
    Summary
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    This study confirms cows' milk-sensitive enteropathy in infants. Serial biopsies effectively diagnose this temporary condition, which typically resolves by age two.

    Area of Science:

    • Pediatric Gastroenterology
    • Immunology
    • Allergy

    Background:

    • Cow's milk protein intolerance is a common concern in infants.
    • Accurate diagnosis is crucial for appropriate management and preventing complications.
    • Previous diagnostic methods may lack definitive confirmation.

    Purpose of the Study:

    • To establish the existence of cow's milk-sensitive enteropathy in infancy.
    • To evaluate the diagnostic utility of serial small intestinal biopsies in response to dietary milk manipulation.
    • To characterize the mucosal lesions associated with cow's milk intolerance.

    Main Methods:

    • Serial small intestinal biopsies were performed in five infants diagnosed with cow's milk protein intolerance.
    • Biopsies were taken during periods of milk withdrawal and subsequent cow's milk challenge.

    Related Experiment Videos

  • Intraepithelial lymphocyte counts were assessed.

    • Main Results:

    • Cow's milk-sensitive enteropathy was clearly established through serial biopsies.
    • Mucosal lesions ranged from partially flat mucosa to mild partial villous atrophy.
    • Intraepithelial lymphocyte counts increased after milk challenge, usually remaining within normal limits.

    Conclusions:

    • Serial biopsies linked to dietary milk challenges provide a reliable method for diagnosing cow's milk intolerance.
    • The condition appears to be transient, typically resolving by two years of age.
    • This diagnostic approach allows for a firm diagnosis based on a single milk challenge.