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Updated: Feb 12, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
Neonatal Herpes Simplex Infection With Extensive Congenital Epidermal Skin Loss: A Report of Four Cases
N T McSwiney1, E Vaughan2, A Phillips3
1University Hospitals Dorset NHS Foundation Trust, Bournemouth, UK.
Abstract:
We describe four cases of neonatal epidermal skin loss presenting at birth, secondary to disseminated herpes simplex virus (HSV) infection. In three, there was a strikingly similar presentation of 80% epidermal skin loss with sparing of the hands, feet, and areas on either the face or scalp. In the fourth neonate, the skin loss was less extensive but followed a similar pattern. This case series highlights an under-recognized pattern of skin involvement in systemic neonatal HSV, and the importance of early recognition and optimal management to improve outcomes.
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