Comparative hemodynamic study of IS-5-MN and ISDN in man--which are equieffective doses?

In a crossover study, the hemodynamic effects of 40 mg sustained release isosorbide dinitrate were compared with those of 40 mg isosorbide-5-mononitrate in 10 patients after myocardial infarction. No differences between both drugs were seen in the magnitude of their effects on cardiac preload. The onset of the effect, however, was faster after IS-5-MN and reached its nadir earlier than after sustained release ISDN. Thus, both drugs are hemodynamically equieffective in equal doses, but their effects show different time courses.