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Coronary vasodilation by nitrates is not mediated by the prostaglandin system: an angiographic and hemodynamic study

I Simonetti, R de Caterina, M Marzilli

    Zeitschrift Fur Kardiologie
    |January 1, 1983
    PubMed

    Insights

    Nitrates do not rely on prostaglandins for coronary vasodilation. Aspirin (ASA) did not affect nitrate-induced vasodilation, indicating prostaglandins are not involved in this process.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Nitrates are commonly used to treat angina.
    • The mechanism of nitrate-induced vasodilation is not fully understood.
    • Prostaglandins are known mediators of vasodilation.

    Purpose of the Study:

    • To investigate the potential role of prostaglandins in mediating coronary vasodilation induced by nitrates.
    • To determine if aspirin (ASA), an inhibitor of prostaglandin synthesis, affects nitrate-induced vasodilation.

    Main Methods:

    • 13 patients were studied.
    • Coronary artery diameter was measured using quantitative magnification coronary angiography.
    • Coronary sinus flow was assessed using coronary sinus thermodilution.
    • Patients received isosorbide dinitrate (ISDN) and aspirin (ASA) via intracoronary and intravenous routes.

    Main Results:

    • Aspirin did not induce significant changes in coronary artery diameter.
    • Aspirin did not prevent isosorbide dinitrate-induced vasodilation.
    • Aspirin did not alter the relative vasodilation induced by isosorbide dinitrate at the coronary resistance level.

    Conclusions:

    • Coronary vasodilation induced by nitrates is not mediated by the prostaglandin system.
    • These findings suggest an alternative pathway for nitrate action in the coronary arteries.

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