Effect of selenium dioxide on the testes of rat

Selenium dioxide was administered (ip) to albino male rats (200 +/- 5 g) in increasing doses (2, 6 and 10 micrograms/rat, daily) for 90 days. Histologic and histometric study showed that there was dose dependent injury to testes. No cellular deformation was observed following 2 micrograms-dose; whereas 6 micrograms-dose caused significant damage of gametogenic cells. At a dose of 10 micrograms, there was a significant testicular degeneration along with testicular atrophy.