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Cardiovascular collapse and propranolol overdose.

N Soni, D Baines, I Y Pearson

    The Medical Journal of Australia
    |December 10, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Propranolol overdose can cause cardiovascular collapse, especially after emetic agents. Atropine administration before emetic compounds, gastric lavage, or intubation may prevent this serious adverse event.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Toxicology

    Background:

    • Beta-blockers like propranolol are widely prescribed for cardiovascular conditions.
    • Emetic compounds are sometimes used in emergency settings to induce vomiting.
    • Cardiovascular collapse is a life-threatening condition characterized by inadequate blood flow.

    Observation:

    • Three cases of propranolol overdose were observed in two patients.
    • Patients experienced cardiovascular collapse following the administration of an emetic compound.
    • The collapse occurred in a hospital casualty department setting.

    Findings:

    • Cardiovascular collapse in this context may be linked to vagal activity potentiated by beta-blockade.
    • Propranolol's action on beta-receptors can exacerbate vagal effects.

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  • The combination of emetic agents and beta-blockade poses a significant risk.

    • Implications:

    • Administration of atropine before emetic compounds, gastric lavage, or intubation is recommended.
    • Atropine may counteract the vagal surge, mitigating the risk of collapse.
    • This finding highlights the importance of considering concomitant medications in overdose management.