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Related Experiment Videos

Red cell distribution width on the Coulter Model S-Plus.

P J Cornbleet, J Buechel

    The American Journal of Medical Technology
    |December 1, 1983
    PubMed
    Summary
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    The Coulter S-Plus red cell distribution width (RDW) has limitations. Sex-dependent normal values and storage issues may affect its accuracy in detecting conditions like iron deficiency anemia.

    Area of Science:

    • Hematology
    • Clinical Pathology
    • Laboratory Medicine

    Background:

    • Red cell distribution width (RDW) is a measure of red blood cell size variation.
    • Accurate RDW measurement is crucial for diagnosing and monitoring various anemias.
    • The Coulter S-Plus is a widely used automated hematology analyzer.

    Purpose of the Study:

    • To evaluate the limitations of the Coulter S-Plus for RDW measurement.
    • To assess the clinical utility of Coulter S-Plus RDW in identifying specific hematological conditions.

    Main Methods:

    • Analysis of RDW values obtained from the Coulter S-Plus analyzer.
    • Comparison of Coulter S-Plus RDW normal ranges with established ranges.
    • Evaluation of RDW stability under room temperature storage conditions.

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  • Assessment of RDW in patients with iron deficiency anemia.

    • Main Results:

    • Coulter S-Plus RDW normal values were found to be sex-dependent (males: 10.7 +/- 2.4; females: 9.8 +/- 1.8).
    • These ranges are broader than the manufacturer's reference range (10.0 +/- 1.5).
    • None of the 29 iron deficiency anemia patients exhibited an elevated RDW using the derived broader ranges.
    • RDW values decreased with room temperature storage, indicating potential instability.

    Conclusions:

    • The Coulter S-Plus RDW measurement has significant limitations, including sex-dependent normal ranges and instability.
    • These limitations may impair its diagnostic utility, particularly for conditions like iron deficiency anemia.
    • Alternative methods for measuring red blood cell volume distribution may be more reliable for quantitating anisocytosis.