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[Polymorphonuclear leukocytes and macrophages in inflammatory and hypersensitive reactions]
Arkhiv Patologii
|January 1, 1983
Summary
Polymorphonuclear leukocytes (PNL) exhibit antimicrobial activity via cation proteins. A novel secretion pathway, proexocytosis, and a diagnostic lysosomal cation test are detailed for various inflammatory conditions.
Area of Science:
- Immunology
- Cell Biology
- Microbiology
Context:
- Polymorphonuclear leukocytes (PNL) are crucial in host defense against microbial infections.
- Understanding the mechanisms of PNL antimicrobial activity is vital for treating inflammatory diseases.
Purpose:
- To summarize morphological aspects of PNL cation protein antimicrobial activity during phagocytosis and inflammation.
- To characterize a novel PNL lysosomal protein secretion pathway, proexocytosis (pseudo-degranulation).
- To propose a lysosomal cation test for clinical prognosis and treatment efficacy evaluation.
Summary:
- Reviews morphological evidence of antimicrobial activity of polymorphonuclear leukocyte (PNL) cation proteins.
- Describes proexocytosis, a new form of PNL lysosomal protein secretion, and hypothesizes nonphagocytic tissue resistance in inflammation.
- Analyzes intracellular microbial parasitism in macrophages and discusses the interplay of immune systems in inflammation.
Impact:
- Introduces a lysosomal cation test for improved diagnosis and prognosis in broncho-pulmonary, surgical, urogenital, burn, and periodontal diseases.
- Outlines strategies for early detection of hereditary lysosomal defects in PNL.
- Contributes to understanding the complex interactions between granulocytic, macrophage, and lymphoid systems in immune responses.