Effect of 1 alpha, 24 R,25-trihydroxycholecalciferol on isolated parathyroid cells secretion

In this work we have studied the action of the trihydroxylated vitamin D metabolite (1 alpha, 24 R,25(OH)3D3) on parathyrin secretion by isolated parathyroid cells. In contrast with the results obtained with mono and dihydroxylated vitamin D, 1 alpha, 24 R,25(OH)3D3 increased the secretion of parathyrin. The effective concentration of this metabolite was 1.54 X 10(-9)M for cells rat and 1.54 X 10(-10)M for human cells.