Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Familial leukemia (author's transl)].

T A Schmitt, L Degos

    Bulletin Du Cancer
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Familial leukemia cases suggest a genetic predisposition, with siblings of patients having a fourfold increased risk. Leukemia onset in twins shows a strong age-dependent risk, highlighting genetic factors in acute and chronic lymphocytic leukemia.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Confronted to medical error, emphasize its positive aspects].

    La Revue de medecine interne·2014
    Same author

    Early death in acute promyelocytic leukemia (APL) in French centers: a multicenter study in 399 patients.

    Leukemia·2014
    Same author

    [Developing health services research in France, one of the HAS missions].

    Revue d'epidemiologie et de sante publique·2008
    Same author

    Treatment of acute promyelocytic leukemia by retinoids.

    Current topics in microbiology and immunology·2007
    Same author

    Late first relapses in APL treated with all-trans-retinoic acid- and anthracycline- based chemotherapy: the European APL group experience (APL 91 and APL 93 trials).

    Leukemia·2006
    Same author

    Extramedullary relapse in acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy.

    Leukemia·2005
    Same journal

    [ONCONNECTE À L'EMPLOI, feedback after three years of a program to prepare for returning to work after cancer in Franche-Comté].

    Bulletin du cancer·2026
    Same journal

    [Off-label use of venetoclax in myeloma].

    Bulletin du cancer·2026
    Same journal

    [Cemiplimab - Adjuvant treatment for the cutaneous squamous cell carcinomas with high risk of relapse, operated and treated by radiotherapy].

    Bulletin du cancer·2026
    Same journal

    Real-world outcomes and management of endometrial cancer in France from 2016 to 2021 (MOONBEAM study).

    Bulletin du cancer·2026
    Same journal

    [Cardiotoxicity in children and adolescents with acute leukemia: Recommendations from the Leukemia Committee of the French Society of Childhood Cancer (SFCE)].

    Bulletin du cancer·2026
    Same journal

    [Reirradiation: A new therapeutic paradigm in oncology].

    Bulletin du cancer·2026
    See all related articles

    Area of Science:

    • Hematology and Oncology
    • Human Genetics and Genomics
    • Epidemiology and Public Health

    Context:

    • Investigates the familial aggregation of acute leukemia, analyzing 26 cases within a cohort of 2966 patients.
    • Examines the increased relative risk of leukemia in siblings and the concordance rates in monozygotic twins.
    • Explores the genetic susceptibility to chronic lymphocytic leukemia and the impact of specific congenital diseases on leukemia risk.

    Purpose:

    • To quantify the familial risk of acute leukemia and understand its inheritance patterns.
    • To assess the age-dependent risk of leukemia in twins.
    • To identify genetic predispositions and associated congenital conditions increasing leukemia susceptibility.

    Summary:

    • Familial cases of acute leukemia were identified, with a significantly higher risk observed in siblings (fourfold increase) and a strong familial clustering.

    Related Experiment Videos

  • Leukemia onset in monozygotic twins demonstrated a pronounced age-dependent risk, with near-certainty if diagnosed before one year old, decreasing thereafter.
  • Chronic lymphocytic leukemia showed evidence of genetic background, and conditions like Down syndrome, Bloom's disease, and ataxia-telangiectasia were linked to elevated leukemia risk.

    • Impact:

    • Provides crucial data for genetic counseling and understanding the heritability of leukemia.
    • Informs targeted screening strategies for high-risk families and individuals with specific genetic syndromes.
    • Contributes to the broader understanding of leukemia etiology, emphasizing the interplay between genetic and environmental factors.