[Genetic and physiological studies of mouse systolic blood pressure]

At the present, it is obviously demonstrated that the blood pressure is genetically controlled. But genetical analysis are not well done because it is very complicated in relation to the environmental factors. In this study, the systolic blood pressure measurement and some blood examinations were carried in 23 inbred strain mice which were relatively representative in different genetical background groups and included 2 diabetic mutants, 1 obese mutant and 1 obese congenic mouse, and the relations were calculated between them. And also the heritability and the number of genetic loci of blood pressure were determined with the hybridization experiment. The results obtained were as follows. About 50 mmHg difference was shown among the blood pressure of different inbred mice. The strains of 129/J, JPW , XP and C57BL/6J indicated lower values, and NZB, ICR, C3H and PL/J strain showed higher blood pressure. Diabetic mutants demonstrated relatively higher values compared with control mice. It was demonstrated that the blood pressure rose high correlatively with the age in the experiment of prediabetic NOD mouse. Remarkable correlations were shown between the blood pressure and serum triglyceride and cholesterol especially in diabetic mice. It was calculated that the blood pressure was controlled by about 5 genetic loci and the heritability was 0.3455.