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Diabetic corneal neuropathy.

R O Schultz, M A Peters, K Sobocinski

    Transactions of the American Ophthalmological Society
    |January 1, 1983
    PubMed
    Summary
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    Asymptomatic corneal lesions in diabetes mellitus are linked to diabetic peripheral neuropathy. Reduced sensation in the toes is the strongest predictor of these diabetic keratopathy lesions.

    Area of Science:

    • Ophthalmology
    • Diabetology
    • Neurology

    Background:

    • Corneal epithelial lesions are common in asymptomatic diabetes mellitus patients.
    • These lesions mimic staphylococcal keratoconjunctivitis but are not necessarily caused by staphylococcal infections.

    Purpose of the Study:

    • To investigate the relationship between diabetic keratopathy and diabetic peripheral neuropathy.
    • To identify predictors of corneal epithelial lesions in patients with diabetes mellitus.

    Main Methods:

    • Analysis of covariance was used to adjust for age.
    • Vibration perception threshold, tear breakup time, diabetes type, and metabolic status (c-peptide fasting) were assessed.
    • Corneal fluorescein staining and keratopathy presence were evaluated.

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    Main Results:

    • Diabetic peripheral neuropathy is significantly related to diabetic keratopathy.
    • Reduced vibration perception threshold in the toes is the strongest predictor of keratopathy and corneal staining.
    • Decreased tear breakup time, diabetes type, and metabolic status also predict keratopathy.

    Conclusions:

    • Asymptomatic corneal epithelial lesions in diabetes mellitus are likely a manifestation of generalized polyneuropathy.
    • These lesions may represent a specific form of corneal neuropathy in diabetic patients.