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Inconsistent leukocyte removal by IBM 2991 blood cell processor.

H Bijou, M T Brady, P Fortes

    Transfusion
    |May 1, 1983
    PubMed
    Summary

    Recent studies show inconsistent leukocyte removal by the IBM 2991 Blood Cell Processor. Changes in the blood product, not the machine, may explain reduced efficiency in removing white blood cells.

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    Area of Science:

    • Transfusion Medicine
    • Hematology
    • Blood Banking

    Background:

    • The IBM 2991 Blood Cell Processor was previously effective for leukocyte removal via saline washing.
    • Inconsistent results in leukocyte removal have been observed recently, diverging from earlier documented efficiencies.

    Purpose of the Study:

    • To evaluate the current efficacy of the IBM 2991 Blood Cell Processor in removing leukocytes.
    • To investigate the reasons behind the observed variability in leukocyte removal efficiency.

    Main Methods:

    • Evaluation of 52 consecutive blood units washed using the IBM 2991.
    • Comparison of current leukocyte removal results with historical data from the 1970s.

    Main Results:

    • Leukocyte removal efficiency in June 1982 varied considerably compared to previous studies.
    • Evidence suggests a recent alteration in the IBM 2991's leukocyte removal capability.

    Conclusions:

    • Alterations in the blood product being washed are a potential cause for inconsistent leukocyte removal.
    • Blood banks must scrutinize washed units for leukocytes and prepare for potential reactions until consistent removal is achieved.

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