Management of essential hypertension with oxprenolol and chlorthalidone in a fixed combination

A study was carried out in 40 patients with mild to moderate essential hypertension. The treatment administered was a fixed drug combination of oxprenolol (160 mg) and chlorthalidone (20 mg) in a single morning dose for 16 weeks. As a result, resting and standing blood pressure decreased significantly) (p less than 0.001). As regards clinical tolerance, this was adequate although treatment had to be discontinued in three patients. The minor side effects observed in other patients did not necessitate withdrawal of therapy. Only minor changes of the biochemical parameters were observed. It may be concluded that some patients with mild to moderate hypertension can be adequately treated with a single daily dose of a fixed drug combination of oxprenolol and chlorthalidone.