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Liposomes from polymerizable phospholipids.

B Hupfer, H Ringsdorf, H Schupp

    Chemistry and Physics of Lipids
    |November 1, 1983
    PubMed
    Summary
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    Researchers synthesized and characterized diacetylene and butadiene phospholipids. Polymerized vesicles show enhanced stability but altered phase transitions, offering insights into membrane properties and potential applications.

    Area of Science:

    • Biochemistry
    • Materials Science
    • Polymer Chemistry

    Background:

    • Phospholipids are fundamental components of biological membranes.
    • Diacetylene and butadiene moieties offer unique polymerization capabilities.
    • Vesicle formation and photopolymerization are key techniques in materials science.

    Purpose of the Study:

    • To synthesize and characterize novel single and double chain phospholipids with diacetylene and butadiene groups.
    • To investigate the photopolymerization of these phospholipids into stable vesicles.
    • To analyze the impact of polymerization on vesicle structure, phase transitions, and stability.

    Main Methods:

    • Synthesis of various single and double chain phospholipids.
    • Ultrasonication for vesicle dispersion in water.

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  • Photopolymerization of lipid vesicles.
  • Absorption spectroscopy for characterization.
  • Ethanol and detergent treatments to assess vesicle stability.
  • Differential scanning calorimetry to study phase transitions.

    • Main Results:

    • Successful synthesis and characterization of diacetylene and butadiene phospholipids.
    • Formation of stable vesicles via ultrasonication and photopolymerization.
    • Polymerized diacetylenic lipids exhibited distinct absorption spectra based on monomer structure.
    • Polymerization suppressed the gel to liquid crystalline phase transition, differing from biological membranes.
    • Polymerized vesicles demonstrated enhanced stability against ethanol and detergents, with reduced marker release.
    • Diacetylenic lipids displayed significant phase transition hysteresis and rapid marker release upon crystallization of supercooled vesicles.

    Conclusions:

    • Photopolymerization of diacetylene and butadiene phospholipids yields stable vesicles with altered membrane properties.
    • The suppressed phase transition and rigidity present challenges for mimicking biological membrane behavior.
    • Further research is needed to overcome membrane rigidity and explore applications of these advanced lipid materials.