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Multi-infarct dementia

V Hachinski

    Neurologic Clinics
    |February 1, 1983
    PubMed

    Insights

    Arteriosclerosis-related strokes damage the brain. Treatments targeting cerebral blood flow for dementia lack scientific basis; focus on stroke prevention and treatment for multi-infarct dementia.

    Area of Science:

    • Neurology
    • Vascular Medicine

    Background:

    • Arteriosclerosis can lead to cerebrovascular damage through strokes.
    • Continuous cerebral ischemia is not a recognized cause of dementia.

    Purpose of the Study:

    • To evaluate the scientific basis for using cerebral vasodilators and "activators" in dementia treatment.
    • To clarify the relationship between cerebral blood flow, metabolism, and dementia.

    Main Methods:

    • Review of existing evidence on arteriosclerosis, stroke, and dementia.
    • Analysis of the causal relationship between decreased cerebral blood flow/metabolism and dementia.

    Main Results:

    • No evidence supports continuous ischemia as a cause of dementia.
    • Decreased cerebral blood flow and metabolism are consequences, not causes, of dementia.
    • Cerebral vasodilators and "activators" lack a scientific basis for dementia treatment.

    Conclusions:

    • Treatment and prevention of multi-infarct dementia should focus on managing and preventing stroke.
    • Interventions targeting cerebral blood flow for dementia are not scientifically supported.

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