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Megacolon at high altitude.

F Patiño, R Ponce, J Lora

    Acta Gastroenterologica Latinoamericana
    |January 1, 1983
    PubMed
    Summary

    Megacolon is common in high altitudes. This study in La Paz found increased bowel motility and low fecal pH in 60 patients, suggesting an acquired condition.

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    Area of Science:

    • Gastroenterology
    • Altitude Medicine
    • Clinical Observations

    Background:

    • Megacolon is frequently observed in high-altitude regions.
    • Previous research on high-altitude megacolon is limited.

    Purpose of the Study:

    • To investigate the characteristics of megacolon in a high-altitude population.
    • To explore potential contributing factors to megacolon in La Paz, Bolivia.

    Main Methods:

    • Observational study of 60 megacolon cases in La Paz (3,600m).
    • Assessment of bowel motility and fecal pH.
    • Histological examination of the nervous plexus and smooth muscle.

    Main Results:

    • Increased motility in both large and small bowels was observed.
    • Feces exhibited a consistently low pH.
    • No histological abnormalities were found in the enteric nervous system or smooth muscle.

    Conclusions:

    • High-altitude megacolon in this cohort appears to be an acquired condition.
    • The findings suggest environmental factors at high altitude may influence bowel function leading to megacolon.

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