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Updated: Oct 2, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
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[Bacterial antibodies and isoagglutinins in intravenous immunoglobulin preparations]

M Haase, H Mengel

    Immunitat Und Infektion
    |June 1, 1983
    PubMed

    Various lots of intravenous immunoglobulins for passive immunization should contain almost the same, broad, antibody profile and provoke very low frequencies of untoward reactions. From 1976-1982 a study was undertaken to measure the level of antibodies directed against tetanustoxin, diphtheriatoxin, streptolysin O, staphylolysin, and salmonella in up to 82 lots. It is interesting to note that the measured level of antibodies in intravenous immunoglobulins varied only slightly as well qualitatively as quantitatively with one exception: an immunoglobulin of placental origin. The amount of tetanusantitoxin in the majority of lots of that preparation was ten-fold lower than that of the other immunoglobulins. Intravenous immunoglobulins contain generally 3-6 IE/ml antistaphylolysin, 600-1200 IE/ml antistreptolysin O, 10-20 IE/ml tetanusantitoxin, and 1-2 IE/ml diphtheriaantitoxin. Antibodies to salmonella could not be demonstrated. Some of the lots exhibited isoagglutinins up to a dilution of 1 : 4.

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