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Related Experiment Videos

Hyperviscosity-induced dementia.

J Mueller, J R Hotson, J W Langston

    Neurology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Dementia can be a reversible symptom of increased serum viscosity caused by multiple myeloma. Plasmapheresis effectively resolved the neurologic issues, highlighting the importance of checking viscosity in dementia cases.

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    Area of Science:

    • Neurology
    • Hematology

    Background:

    • Dementia presents a complex diagnostic challenge with numerous potential etiologies.
    • Multiple myeloma is a hematologic malignancy with diverse clinical manifestations.

    Observation:

    • A patient presented with dementia as the primary symptom.
    • The dementia was found to be secondary to significantly increased serum viscosity.
    • The underlying cause of hyperviscosity was identified as multiple myeloma.

    Findings:

    • Plasmapheresis, a procedure to remove plasma, resulted in the complete resolution of the patient's neurologic symptoms.
    • This case demonstrates a direct link between serum hyperviscosity and dementia.

    Implications:

    • Serum hyperviscosity should be considered a potentially reversible cause of dementia.

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  • Diagnostic evaluation for dementia should include serum and whole blood viscosity measurements when hyperviscosity is suspected.