[Various neurochemical mechanisms of growth of cerebral dysontogeneses]

The development and preservation of conditioned reflexes of passive and active avoidance, behaviour in "the open field", as well as the sensitivity to spasmodic agents were investigated in rats that had suffered acute intrauterine hypoxia, perinatal asphyxia, and exposure to ethanol in the antenatal period. The findings obtained were correlated with the parameters of protein biosynthesis which were considerably altered in some brain structures of the experimental animals. It is suggested that disturbances in protein metabolism in the central nervous system play an important role in the development of long-term manifestations of the deleterious action of pathogenic factors on the developing brain in the antenatal period.