[Formation of malondialdehyde during liposome interaction with cells]

When AKE cells and leukocytes interact with egg lecithin liposomes malone dialdehyde (MDA) is formed and accumulated in the incubation medium. When synthetic dipalmitoyl--lecithin is used and at heat or hypotonic cell damage the rate of MDA accumulation abruptly decreases. The maximal rate of MDA accumulation in case of natural lecithin is (1.25 +/- 0.05) . 10(-15) mole of MDA per cell/hour. It is suggested that the sources of MDA are higher unsaturated fat acids of natural liposomal lipids, whose oxidation is performed by intact cells, possibly with the participation of active forms of oxygen.