Anxiogenic action of a convulsant benzodiazepine: reversal by chlordiazepoxide

Ro5-3663, a convulsant benzodiazepine and a ligand for CNS picrotoxin sites, but not for benzodiazepine sites, had a significant dose-related (2 and 4 mg/kg) anxiogenic action in the social interaction test of anxiety. This anxiogenic effect was reversed by chlordiazepoxide (5 mg/kg).