Ototoxicity of cis-dichlorodiammine platinum (II) in guinea pigs

Effects of cis-dichlorodiammine platinum (II), an agent that has potent antineoplastic activity, were studied in guinea pigs. With repeated administration of a daily dose of 1.5 mg/kg of cis-dichlorodiammine platinum, the cochlear microphonics were suppressed. Suppression of the cochlear microphonics was greater in the basal turn than in the third turn of the cochlea. There was a close correlation between loss of the cochlear hair cells and suppression of the cochlear microphonics. The endocochlear potential was decreased in the basal turn but remained unchanged in the upper turn of the cochlea. The sodium, potassium, and chloride concentrations in both endolymph and perilymph were not affected. Slight and moderate congestion and regeneration of tubular epithelium of kidney were observed in guinea pigs treated with cis-dichlorodiammine platinum.