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Right and left ventricular flow during mechanical alternans.

Y Hasin, A Findler, S Rogel

European Journal of Cardiology

|April 1, 1978

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Mechanical alternans in dog ventricles can shift to new steady states with single premature or delayed beats. Ventricular alternans and flow disparities were observed, suggesting complex cardiac dynamics.

Area of Science:

Cardiology
Physiology

Background:

Mechanical alternans, characterized by alternating beat strength, can occur during rapid heart rhythms.
Understanding alternans is crucial for comprehending cardiac function under stress.

Purpose of the Study:

To investigate the impact of premature or delayed beats on mechanical alternans in canine ventricles.
To analyze the relationship between ventricular alternans and associated blood flow dynamics.

Main Methods:

Measurements of pulmonary and aortic blood flow and ventricular isometric tension in anesthetized dogs.
Induction of mechanical alternans via rapid atrial pacing.

Main Results:

Steady states of mechanical alternans could be altered by single premature or delayed beats.

Related Experiment Videos

Ventricular alternans force was not consistently equal between right and left ventricles.

Pulmonary and aortic flow varied significantly with altered alternans states, even at constant heart rate.

Inequality in ventricular alternans was linked to disparities in aortic and pulmonic flow.

Conclusions:

Single ectopic beats can modify ventricular mechanical alternans.
Asynchronous ventricular alternans can lead to significant disparities in cardiac output.
Findings highlight potential mechanisms and clinical relevance of alternans in cardiac function.