[Isolation of a group at risk for stomach cancer based on genetic and epidemiological study data]

The predictive value of risk factors of stomach cancer was studied on the basis of the results of a complex genetico-epidemiologic survey conducted with a view to identifying the group at risk. An optimal combination of these factors and the multifactor method of mathematical statistics were used in working out a decision instruction. Application of the latter offers an 80% credibility in selecting persons at high risk for stomach cancer development. The paper deals with the findings on a significant relationship between stomach cancer development and genetic and familial factors as well as on indications at certain changes in gastrointestinal function observed before clinical manifestation of the disease. The results point to the efficacy of complex clinical, genetic and epidemiologic studies conducted for prediction of neoplasms caused by a set of factors.