Implications of rapid uniform density changes on hepatic computed tomography

Uniform hepatic density alterations may be due to fatty infiltration or hemochromatosis. Whole liver density pattern changes may occur with rapidity where there is liver fat accumulation or mobilization. Averaged hepatic densities from concomitantly increased fat and iron accumulation can result in a false impression of liver normalcy. Two cases are presented to illustrate these points and the importance of understanding the patterns in terms of pathophysiology and response to treatment.