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Gc subtypes in Northern Indians.

S Karlsson, I Skaftadóttir, A Arnason

    Human Heredity
    |January 1, 1983
    PubMed
    Summary
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    This study analyzed Gc subtypes in North Indian individuals residing in Birmingham, UK. Gene frequencies for Gc1F, Gc1S, and Gc2 were determined using isoelectric focusing, with no variant alleles found.

    Area of Science:

    • Genetics
    • Population Genetics
    • Biochemistry

    Background:

    • The Gc (vitamin D binding protein) system is a polymorphic protein system.
    • Understanding Gc subtype distribution is crucial for population genetics and anthropological studies.

    Purpose of the Study:

    • To determine the gene frequencies of Gc subtypes (Gc1F, Gc1S, Gc2) in a population sample of North Indians living in Birmingham, UK.
    • To identify any variant alleles within this population group.

    Main Methods:

    • Isoelectric focusing (IEF) was employed for Gc subtype phenotyping.
    • Gene frequencies were calculated based on the typed individuals.

    Main Results:

    • The observed gene frequencies were Gc1F = 0.191, Gc1S = 0.519, and Gc2 = 0.290.

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  • A total of 243 individuals were typed.
  • No variant alleles were detected in the studied population.

    • Conclusions:

    • The Gc subtype gene frequencies in this North Indian population sample living in the UK are established.
    • The absence of variant alleles suggests a homogeneous genetic profile for the Gc system in this group.