Evidence for 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) as a proaggregating agent in rat and human platelets

In view of the established biological role for 1,25-dihydroxycholecalciferol (DHCC) in calcium mobilization and the significance of calcium availability in platelet activation, it was of interest to investigate the potential for DHCC to act as a proaggregating agent. The present results provide evidence that DHCC at a concentration of 0.01 micrograms/microL can both aggregate human platelets and potentiate ADP-induced platelet aggregation. DHCC was also capable of aggregating rat platelets.