[Correlation between tumor growth and proteic variations in interstitial liquid and serum]

The growth of four chemio-induced tumours has been studied in correlation with the proteic variations in interstitial subcutaneous liquid and serum revealed by polyacrylamide gel electrophoresis. We could notice important changes in three proteic groups: beta-lipoproteins, transferrin and alpha-globulins. A significant increase is recorded for these 3 proteic groups in intersitial fluid and only for alpha-globulins in serum for the tumours growing the slowest. By contrast, a significant decrease of these 3 proteic groups is recorded in interstitial liquid of mice which bear the faster-growing tumours.