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Design and methods in a multi-center case-control interview study.

P Hartge, J I Cahill, D West

    American Journal of Public Health
    |January 1, 1984
    PubMed
    Summary
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    This case-control study interviewed 2,982 bladder cancer patients and 5,782 controls across the US. It details methods to ensure high-quality data in multi-center epidemiologic research.

    Area of Science:

    • Epidemiology
    • Public Health
    • Cancer Research

    Background:

    • Bladder cancer is a significant public health concern.
    • Accurate data collection is crucial for understanding disease etiology.
    • Multi-center studies present unique methodological challenges.

    Purpose of the Study:

    • To describe the design and field methods of a large-scale case-control study on bladder cancer.
    • To present techniques for bias reduction and data quality monitoring.
    • To offer insights applicable to future epidemiologic research.

    Main Methods:

    • Case-control study design.
    • Interviews with 2,982 bladder cancer patients and 5,782 population controls.
    • Implementation of novel and established methods for data quality assurance.

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    Main Results:

    • The study successfully collected data from a large cohort across ten US regions.
    • Various techniques were employed to minimize bias and ensure data integrity.
    • Detailed methodology provides a framework for similar epidemiological investigations.

    Conclusions:

    • The described methods are robust and adaptable for multi-center interview-based epidemiologic studies.
    • Rigorous methodological approaches are essential for reliable findings in cancer research.
    • This study serves as a model for quality-controlled data collection in population studies.