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Related Experiment Videos

The transient global amnesia-migraine connection.

G F Crowell, D A Stump, J Biller

    Archives of Neurology
    |January 1, 1984
    PubMed
    Summary

    Transient global amnesia (TGA) may be linked to migraine-related cerebral blood flow changes. Impaired blood flow patterns in TGA patients differ from other transient ischemic attacks, suggesting a unique pathophysiology.

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    Introductory remarks.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015

    Area of Science:

    • Neurology
    • Neuroimaging
    • Vascular Neurology

    Background:

    • Transient global amnesia (TGA) is a distinct neurological condition characterized by sudden, temporary memory loss.
    • The underlying pathophysiology of TGA remains incompletely understood.
    • Migraine is a common neurological disorder, and its association with TGA has been hypothesized.

    Observation:

    • This study investigated regional cerebral blood flow (rCBF) in twelve patients experiencing TGA.
    • Seven patients (58%) reported headaches during their TGA episodes, and five (42%) were diagnosed migraineurs.
    • Regional cerebral blood flow was measured using the xenon Xe 133 inhalation method.

    Findings:

    • Five of seven tested patients exhibited abnormal rCBF patterns.
    • These abnormalities included impaired vasomotor response in watershed areas and/or focal ischemia in the inferior temporal lobe.
    • The observed rCBF patterns in TGA were distinct from those typically seen in carotid or vertebrobasilar transient ischemic attacks (TIAs).

    Implications:

    • The findings suggest that vasomotor phenomena, potentially linked to migraine, may play a significant role in the etiology of TGA.
    • This research differentiates TGA pathophysiology from other cerebrovascular events like TIAs.
    • Further investigation into the migraine-TGA connection could reveal new diagnostic and therapeutic targets.

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