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Transglottic carcinoma.

B Mittal, J E Marks, J H Ogura

    Cancer
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Transglottic carcinoma treatment outcomes vary by approach. Total laryngectomy showed fewer local failures than voice conservation surgery, but survival rates were similar after salvage. Voice preservation was achieved in most patients undergoing less invasive treatments.

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    Area of Science:

    • Otolaryngology
    • Surgical Oncology
    • Head and Neck Cancer Research

    Background:

    • Transglottic carcinoma presents unique treatment challenges.
    • Neck node metastasis is a significant concern in these patients.
    • Treatment decisions are often guided by lesion size and patient condition.

    Purpose of the Study:

    • To evaluate treatment outcomes for transglottic carcinoma.
    • To compare different treatment modalities including surgery and radiation.
    • To identify prognostic factors influencing survival and recurrence.

    Main Methods:

    • Retrospective review of 152 transglottic carcinoma cases.
    • Analysis of treatment approaches: voice conservation surgery (VCS), total laryngectomy (TL), and radiation alone (RA).

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  • Evaluation of failure rates, voice preservation, complications, survival, and second tumor incidence.

    • Main Results:

    • Total laryngectomy +/- neck dissection +/- radiation (TL +/- ND +/- R) had lower primary/stomal failure rates (12%) compared to VCS +/- ND +/- R (23%) and RA (33%).
    • Voice preservation rates were 60% for VCS and 67% for RA.
    • Five-year survival was 47% observed and 55% adjusted; higher mortality in the RA group was due to intercurrent disease.

    Conclusions:

    • While TL +/- ND +/- R may offer better local control for larger transglottic carcinomas, ultimate survival is comparable after salvage.
    • VCS +/- ND +/- R is associated with higher complication rates.
    • Advanced stage, older age, and positive surgical margins/nodes are unfavorable prognostic factors.